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Mueller, Gregory M. Bills, and Mercedes S.

Taxus baccata

Foster eds. Elsevier Academic Press, Elsevier B. ISBN: The Genus Taxus. Hideji,Itokawa and Lee Kuo-Hsiung eds. ISBN Bioactivity and Therapeutic Potential.

Taxus: the genus taxus | Hideji Itokawa, Kuo-Hsiung Lee | download

Zhen, Youn-su ed. Cycad Classification. Concepts and Recommendations. Terrence Waiters and Roy Osborne eds. Tree Ferns. Mark F. Large and John E. The Genus Artemisia. Wright, Colin W. Hardman, Roland series ed. Cinnamon and Cassia. The Genus Cinnamomum. Ravindran, P. Nirmal Bamu, and M. Shylaja eds. Hardman, Roland.


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    Due to the enormous propensity of plants that synthesize mixtures of structurally diverse bioactive compounds, the plant kingdom is potentially a very diverse source of chemical constituents with tumor cytotoxic activity. Despite the successful utilization of few phytochemicals, such as vincristine and taxol, into mainstream cancer chemotherapy, commercial plant-derived anticancer formulations represent only one-fourth of the total repertoire of the available treatment options.

    Though significant progress has been made towards the characterization of isolated compounds and their structure-related activities, the complex composition of plant extracts, along with the lack of reproducibility of activity and the synergy between different, even unidentified, components of an extract, prohibits the full utilization of plants in pharmaceutical research. In this review, the results of an extensive literature survey on the anticancer properties of terrestrial plants, covering a thirty-five-year-long span — are presented. A total of plant species, belonging to genera and 61 families have been identified as an active or promising source of phytochemicals with antitumor properties, corresponding to a 41 percent increase during the last five years.

    Among them, only 15 species belonging to ten genera and nine families have been utilized in cancer chemotherapy at a clinical level, whereas the rest of the identified species are either active against cancer cell lines or exhibit chemotherapeutic properties on tumor-bearing animals under experimental conditions. Phenylpropanoids are the most widely distributed compounds 18 families , followed by terpenoids 14 families , and alkaloids 13 families.

    Tree id Himalayan Yew tree - Taxus wallichiana East Himalayan Yew identification and profile uk

    Analytical, species-specific information on bioactive constituents and target cancers is provided. The outlook of phytochemistry-based cancer therapy is discussed, particularly in the perspective of identifying immunomodulatory anticancer agents with minimal toxicity on healthy tissues.

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    I wish to express my warmest thanks to Mrs. The assistance of Mrs. Ioanna Marinopoulou and Mrs. Hara Korea in compiling the list of references is also acknowledged. Lemmons: pt. Roth, Ingrid, and Helga Lindorf. South American medicinal plants: botany, remedial properties, and general use. Schultes, Richard Evans, and Robert F. The healing forest: medicinal and toxic plants of the northwest Amazonia.

    Tibetan medicinal plants. Edited by Christa Kletter and Monika Kriechbaum.


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    Biologically active natural products: pharmaceuticals. Edited by Stephen J. Cutler and Horace G. B57 Dewick, Paul M. Medicinal natural products: a biosynthetic approach. Chichester, Eng. D48 Ebadi, Manuchair S. Pharmacodynamic basis of herbal medicine. Evans, William Charles. Edinburgh, New York, W. Saunders, Huang, K. The pharmacology of Chinese herbs. Li, Thomas S. Chinese and related North American herbs: phtyopharmacology and therapeutic value s.

    Medicinal plants: culture, utilization, and phytopharmacology. Lancaster, PA, Technomic Pub. L Natural medicines comprehensive database. Science RR has most recent edition. Polya, Gideon Maxwell. Biochemical targets of plant bioactive compounds: a pharmacological reference guide to sites of action and biological effects. Williamson, Elizabeth M. Okpako, and Fred J.